摘要
目的评价拉米夫定(LMD)联合干扰素(INF)治疗慢性乙型肝炎(CHB)的疗效和安全性,探讨二者联合治疗的协同作用。方法将185例HBV-DNA和HBeAg阳性的CHB患者随机分为A、B、C三组:A组采用LMD与INF联合治疗,B组单用LMD治疗,C组单用INF治疗。A、B两组LMD均为100mg/d,口服,12个月为1疗程,但A组于LMD治疗第7个月开始加用INF 3MU,3次/周,6个月为1疗程;C组单用INF 3MU,3次/周,6个月为1疗程。三组均在1疗程结束时进行疗效评价,治疗结束后随访12个月。结果疗程结束时,A、B两组ALT复常率、HBV-DNA阴转率差异无统计显著性(P>0.05),A组HBeAg阴转率、HBeAg/抗-Hbe血清转换率均显著高于B组,差异有统计显著性(P<0.05);A、C两组比较,A组以上四项指标均显著高于C组,差异有统计显著性(P<0.05)或高度统计显著性(P<0.01)。随访结束时,A组以上指标均显著高于B、C组,差异有统计显著性(P<0.05)或高度统计显著性(P<0.01)。结论LMD联合INF治疗CHB疗效明显优于单用LMD或INF,是CHB患者安全而较有效的治疗方法。
Objective To evaluate the efficacy and safety of lamivudine（LMD） combined with interferon（INF） on chronic hepatitis B （CHB） and to discuss the cooperating effect of LMD and INF combination therapy. Method One hundred and eighty-five CHB patients with positive HBV-DNA and HBeAg were randomly divided into three groups. Group A, B and C were treated with LMD and IFN combination, LMD or IFN alone respectively. The patients in both groups A and B received LMD 100 mg/d orally, 12 months as a course. But the patients in group A received IFN 3MU from the 7th month,three times weekly,6 months as a course. The patients in group C received IFN 3MU, three times weekly,6 months as a course. The effects were evaluated at the end of a course. All patients were followed up for 12 months after finishing the treatment. Results When a course had been taken, there were no significant statistical differences both in the normalization rate of ALT and the lose rate of serum HBV-DNA between group A and group B （ P 〉 0.05）. The lose rate of HBeAg and seroconversion rate of HBeAg/anti-HBe in group A were significandy higher than those in group B （P 〈 0. 05 ）. The four indexes in group A were significantly higher than those in group C（ P 〈 0.05 or 〈 0.01 ）. At the end of follow up, the indexes in group A were significandy higher than those in both group B and C （P 〈 0.05 or 〈0.01 ）. Conclusions LMD and IFN combination therapy is effective and safe for CHB patients. Its efficacy is superior to LMD or IFN only.
出处
《现代诊断与治疗》
CAS
2008年第4期204-206,共3页
Modern Diagnosis and Treatment
关键词
慢性乙型肝炎
拉米夫定
干扰素
联合治疗
Chronic hepatitis B
Lamivudine
Interferon
Combination therapy
