摘要
目的:观察槲皮素对实验性非细菌性前列腺炎的治疗效果。方法:采用五种模型、包括消痔灵诱导的大鼠慢性前列腺炎模型、角叉菜胶诱导的急性前列腺炎模型、巴豆油致耳肿胀模型、光刺激致痛模型、棉球肉芽肿模型及体外测定离体家兔尿道平滑肌张力试验,观察槲皮素的作用。结果:槲皮素对大鼠急慢性非细菌性前列腺炎具有良好的抗炎作用,对耳肿胀试验、肉芽肿试验及光刺激致痛试验具有良好的抑制作用,并对离体的尿道平滑肌具有较好的舒张作用。结论:槲皮素对实验性非细菌性前列腺炎具有良好的抑制作用,并对尿道平滑肌具有一定舒张作用,提示槲皮素具有良好的临床治疗非细菌性前列腺炎作用,并能缓解排尿困难症状。
AIM： To study the anti-inflammatory effects of quercetin on the experimental animal models of abacterial prostatitis.METHODS： Five types of experimental animal inflammatory models in vivo were applied to investigate the anti-inflammatory and analgesic effects of quercetin,including xiaozhiling-induced chronic prostatitis,carrageenan-induced acute prostatitis,croton oil-induced auricle swelling,photothermal stimulation-induced pain,cotton ball granuloma test of mice,and the rabbit urethral smooth muscle tensile test in vitro to examine the catabatic effects on dysuria.RESULTS： Quercetin displayed good anti-inflammatory effects on acute and chronic abacterial prostatitis.Quercetin also had good inhibitory effects on croton oil-induced auricle swelling,photothermal stimulation-induced pain and cotton ball granuloma test of mice and had definite relaxing effects on rabbit urethral smooth muscle.CONLUSION： It indicates that quercetin has good therapeutic effects on abacterial prostatitis and could alleviate dysuria.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2008年第6期648-653,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
浙江省中医药科研基金计划项目(2006C039)
关键词
槲皮素
前列腺炎
治疗
quercetin
prostatitis
therapeutic
