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托拉塞米注射剂治疗慢性充血性心衰伴水肿临床随机对照研究 被引量:2

Clinical randomized controlled trial on torasemide injection in treating patients with congestive heart failure and edema
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摘要 目的:评价国产托拉塞米注射剂治疗慢性充血性心衰伴水肿的临床疗效与安全性。方法:采用随机对照单盲法平行试验设计,试验组采用托拉塞米注射剂,对照组采用呋塞米注射剂。共入选208例患者,可评价病例201例。观察试验组与对照组用药疗效与安全性。结果:试验组和对照组有效率分别为99.0%及96.1%;试验组与对照组用药后24小时尿量均较治疗前明显增加;试验组和对照组不良反应发生率分别为3.88%和2.88%(P>0.05)。结论:托拉塞米注射剂治疗慢性充血性心衰伴水肿临床疗效好,使用安全、方便,有较高的临床应用价值。 AIM: To evaluate the efficacy and safety of torasemide injection in the treatment of congestive heart failure with edema.METHODS: A total of 208 patients were enrolled in this clinical randomized controlled trial,but 7 cases were not included in the statistics.Patients in Trial Group were treated with torasemide injection,those in Control Group were treated with furosemide injection.RESULTS: The effective rates of torasemide injection and furosemide injection were 99.0% and 96.1% respectively.There were no significant diference(P〉0.05) between the two groups.The 24 h volume of urine was significantly increased in both groups.The incidence rates of adverse drug reactions(ADR) of torasemide injection and furosemide injection were 3.88% and 2.88% respectively.CONCLUSION: Torasemide injection is an effective and safe drug for the treatment of congestive heart failure with edema.
出处 《中国临床药理学与治疗学》 CAS CSCD 2008年第6期699-703,共5页 Chinese Journal of Clinical Pharmacology and Therapeutics
关键词 托拉塞米 呋塞米 慢性充血性心衰 水肿 随机对照试验 torasemide furosemide chronic congestive heart failure edema randomized controlled trial
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参考文献9

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