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抗心律失常药物致心律失常作用的机制 被引量:7

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摘要 服用治疗量抑或亚治疗量抗心律失常药物(AAD)的治疗过程中,引起原有心律失常加重或者诱发新的心律失常称为AAD致心律失常(proarrhythmia)作用。自1989年心律失常抑制实验(CAST)结果公布后.AAD致心律失常的作用被认为是AAD引起死亡率增高的主要原因,因而受到广泛重视,现证实不论是传统还是新型的AAD,均有致心律失常作用,其发生率与检测方法和药物特性有关,采用动态心电图或心电生理检查方法检出AAD致心律失常的发生率分别为10%和20%,
出处 《内科理论与实践》 2008年第4期232-234,共3页 Journal of Internal Medicine Concepts & Practice
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