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七氟醚、异氟醚不同呼气末浓度对熵和脑电双频指数的影响 被引量:10

Effects of different end-tidal concentration of sevoflurane and isoflurane on entropy and BIS
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摘要 目的观察不同呼气末浓度的七氟醚和异氟醚对熵、脑电双频指数(BIS)及血流动力学的影响。方法40例ASAⅠ或Ⅱ级全麻手术患者随机均分为七氟醚组(Ⅰ组)和异氟醚组(Ⅱ组)。麻醉诱导用丙泊酚1mg/kg,1min后吸入七氟醚或异氟醚;维持反应熵(RE)、状态熵(SE)、BIS45~55,6min后置入喉罩。调节吸入浓度使两组患者呼气末浓度分别为0.4、0.6、0.8、1.0和1.3MAC时各维持10min,记录RE、SE、BIS、HR和MAP。结果两组患者不同呼气末浓度七氟醚和异氟醚RE、SE、BIS随浓度增加而逐渐下降(P〈0.05),HR逐渐减慢、MAP逐渐降低(P〈0.05)。两组间各指标差异均无统计学意义。RE、SE、BIS间直线相关性随呼气末浓度增大相关系数有增加趋势。结论熵和BIS均能有效监测七氟醚、异氟醚麻醉深度。 Objective To observe the effects of sevoflurane or isoflurane inhalation on entropy, BIS, MAP and HR. Methods Forty ASA class Ⅰ or Ⅱ patients were randomly allocated to group Ⅰ (sevoflurane group) and Ⅱ (isoflurane group). At Ⅰ min after intravenous propofol 1 mg/kg, the patients inhaled 8%-5% sevoflurane (group Ⅰ ) or 5%-3% isoflurane (group Ⅱ ) with 7-4 L/min O2 to maintain state entropy (SE), response entropy (RE), and bispectral index (BIS) 45-55. Six rain later, larygeal mask airway (LMA) was inserted. SE, RE, BIS, MAP and HR were recorded at the time when the MAC of sevoflurane or isoflurane was maintained at 0.4, 0.6, 0.8, 1.0, or 1.3 for 10 min respectively. Results Sevoflurane or isoflurane decreased SE, RE, BIS, MAP and HR significantly at every end-tidal concentration (P〈 0.05). Entropy and BIS had higher linear correlation with the increase of the depth of anesthesia. Conclusion Entropy and BIS are able to monitor the depth of anesthesia during sevoflurane or isoflurane inhalation.
出处 《临床麻醉学杂志》 CAS CSCD 2008年第7期571-573,共3页 Journal of Clinical Anesthesiology
基金 广州市卫生局立项资助(编号2005-YB-045)
关键词 脑电双频指数 麻醉深度 七氟醚 异氟醚 Entropy Bispectral index Depth of anesthesia Sevoflurane Isoflurane
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