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对苯二酚诱导293T细胞凋亡的研究 被引量：3

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摘要 目的在体外实验探讨对苯二酚对细胞的毒性机制。方法采用MTT比色、DNA凝胶电泳、流式细胞术来检测其对苯二酚对293T细胞的影响。结果对苯二酚对293T细胞的生长具有明显的抑制作用,且随着对苯二酚浓度的增加对293T细胞生长抑制愈加明显;293T细胞经80μM对苯二酚作用后,凋亡率达到70%;琼脂糖凝胶电泳显示细胞DNA呈梯状降解。结论对苯二酚在体外能够明显抑制293T细胞的增长,其毒性作用可能与诱导细胞凋亡有关。
作者 奉友刚 高振利 王科 王琳 刘晓风 刘玲玲
机构地区 青岛大学附属烟台毓璜顶医院泌尿外科
出处 《中国医刊》 CAS 2008年第8期52-53,共2页 Chinese Journal of Medicine
关键词 对苯二酚 293T细胞 凋亡
分类号 R737.32 [医药卫生—肿瘤]
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共引文献19

同被引文献42

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中国医刊
2008年 第8期

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