摘要
目的评价类风湿关节炎(RA)患者抗环瓜氨酸肽(抗CCP)抗体阳性率以及抗CCP抗体与关节外受累的关系。方法115例患者入选中晚期RA(LRA)组,病程大于2年。39例患者入选早期RA(ERA)组,病程小于2年。抗CCP抗体和类风湿因子(RF)分别采用酶联免疫吸附试验(ELISA)和散射速率比色法测定。结果LRAS组共45例(39%)患者具有关节外受累;LRA组,骨侵蚀与病程正相关(r=0.24,P<0.01),骨侵蚀与类风湿因子(RF)正相关(r=0.29,P<0.002),骨侵蚀与抗CCP抗体正相关(r=0.21,P<0.02);RF与抗CCP抗体正相关(r=0.32,P<0.0001)。结论抗CCP抗体与疾病的严重性和骨侵蚀有关。
Objective To evaluate the positive frequency of anti-cyclic citrulline peptide antibody （anti-CCP） in rheumatoid arthritis patients and their relationship with extra-articular manifestations of rheumatoid arthritis （ RA）. Methods One hundred and fifteen RA patients were classified into long-standing RA group （ LRA ） whose disease duration was longer than 2 years. Thirty-nine patients were included in the early RA （ ERA） group （ 〈 2 years ）. Anti-CCP antibody and rheumatoid factor （ RF） were evaluated with enzyme linked immunosorbent assay kits and standard nephelometry methods, respectively. Extra-articular manifestations were diagnosed by relevant criteria. Results The total number of patients with extra-articular manifestations was found to be 45 （ 39% ）. No significant difference was found between LRA group and ERA group in terms of extra-articular manifestations. There were no differences between both groups regarding the number of patients with positive anti-CCP antibody and the levels of anti-CCP antibody. In LRA group, there was a positive correlation between erosion and disease duration （ r = 0. 24, P 〈 0.01） , between erosion and RF （ r = 0. 29, P 〈 0. 002 ） , and between erosion and anti-CCP antibody （ r = 0. 21, P 〈 0. 02 ）. Positive correlation between RF and anti-CCP antibody （ r = 0. 32, P 〈 0. 0001） , between subcutaneous nodule and lung involvement （ r = 0. 24, P 〈 0. 008 ） was found in the LRA group. Conclusion Anti-CCP antibody is associated with the severity of the disease and bone erosion.
出处
《实用医院临床杂志》
2008年第4期73-75,共3页
Practical Journal of Clinical Medicine
关键词
抗环瓜氨酸肽抗体
关节炎
类风湿
类风湿因子
关节外受累
Anti-cyclic citrulline peptide antibody
Arthritis
Rheumatoid
Rheumatoid factors
Extra-articular involvement
