摘要
目的观察丁丙诺啡不同组方用于术后硬膜外腔自控镇痛临床镇痛效果及副作用。方法硬外麻下行腹部手术病人40例，按镇痛液配方分为两组。Ⅰ组（丁布氟液，n=20例）：丁丙诺啡0．75mg、氟哌啶5mg、0．5％布比卡因25ml加生理盐水100ml；Ⅱ组（丁布氟芬液，n=20例）：Ⅰ组配方加芬太尼0．2mg。手术至关腹时将PCA泵连接硬膜外导管并注入负荷量后术后镇痛48～72h。观察两组复合液的镇痛效果（优、良、差）及副作用。结果术后首24h丁丙诺啡用量、PCA按压次数，两组无明显差异（p〉0．05）。两组镇痛效果优：Ⅰ组14例（70％），Ⅱ组19例（95％），两组差异有显著意义（p〈0．05）；良：Ⅰ组6例（30％），Ⅱ组1例（5％），两组差异有显著意义（p〈0．05）；两组均无差级病例。两组病人均未发生恶心、呕吐、皮肤瘙痒、尿潴留和明显的呼吸抑制；个别有嗜睡、口干和头晕。结论丁丙诺啡复合氟哌啶、芬太尼多模式手术后硬膜外腔病人自控镇痛效果好，副作用少。
Objective To observe the clinical effect of buprenorhine combined with different formula for patient＇ s self - control epidural analgesia and the side effect. Methods 40 cases undergone continuous epidural anesthesia, they were divided into two groups randomly, according to the different formula, the formula in group 1 （n =20 cases ） was buprenorphine combined with droperidol, and the formula in group 2 （ n = 20 cases ） was buprenorphine combined with droperidol and fentanyl. They were connected the PCA pump after operation. The relieve pain and side effect during analgesia were recorded, there were three grades on the effect of relieve pain, that were excellent, fine and bad respectively. Results There was no difference in the volume of buprenorphine consumption in the two groups at the first day in postoperative, the ratio of excellent analgesia was higher in group 2 than that in group 1, that was 70% in groupl and 95% in group 2, there was significant difference（p 〈0.05）. The nausea, vomit, dizzy and itch of skin, retention of urine, serious respiratory depression were not occurred during analgesia. Conclusion Buprenorphine combined with droperidol and fentanyl is good for patient＇ s self - control epidural analgesia in postoperative period, there is no side effect obviously.
出处
《现代医院》
2008年第8期21-22,共2页
Modern Hospitals
关键词
药物
手术后镇痛
病人自控镇痛
多模式镇痛
Drug, Postoperative analgesia, Patient＇s self-control analgesia, Multimodal analgesia
