摘要
[目的]预测非洲猪瘟病毒VP73蛋白的B细胞表位。[方法]综合分析二级结构、亲水性、表面可及性与抗原性指数，预测非洲猪瘟病毒VP73蛋白的抗原表位。[结果]推测B细胞表住位于非洲猪瘟病毒VP73蛋白N端的11－18、26—48、73－82、136—150、159－174、181－189、191－210、247—276、279－295、313－323和382—392区段内或上述区段附近。[结论]应用多参数预测非洲猪瘟病毒VP73蛋白的B细胞表位，为今后进一步研究非洲猪瘟病毒VP73蛋白的特征以及表位疫苗的研制奠定了基础。
[Objective]The B cell epitopes for VP73 protein of African swine fever virus was predicted. [Methed]Based on the analysis of the amino acid sequence and the flexible regions of VP73 protein,the B cell epitopes for VP73 protein of African swine fever virus were predicted by method of Kyte-Doolittle,Emini and Jameson-Wolf. [Result]The B cell epitopes were located at or adjacent to the N-terminal No.11-18,26-48,73-82,136-150,159-174, 181-189,191-210,247-276,279-295,313-323 and 382-392. [Conclusion]The multi-parameters analytic method was adopted to predict the B cell epitopes for VP73 protein of African swine fever virus,which laid solid foundation for further characterizing the protein of VP73 and researching epitope vaccine.
出处
《安徽农业科学》
CAS
北大核心
2008年第18期7680-7682,共3页
Journal of Anhui Agricultural Sciences
