摘要
目的:探讨多帕菲联合铂类治疗复发卵巢癌的近期疗效和毒副反应。方法:多帕菲75mg/m2,静脉滴入1h,d1;铂尔定按Auc为5,根据体表面积肌酐清除率计算,d1;每周期间隔21～28d,至少应用2周期。结果:完全缓解22例,部分缓解19例,总有效率为70.7%(41/58)。毒副反应主要表现为轻和中度的骨髓抑制、恶心、呕吐及脱发等。结论:多帕菲联合铂类治疗复发卵巢癌有较好的近期疗效,毒副反应较小,临床上可以接受。
OBJECTIVE： To evaluate the efficacy and side effects of docetaxel combined with platinum in the treatment of re current ovarian carcinoma. METHODS： Fifty-eight cases of recurrent ovarian carcinoma were treated with docetaxel 75 mg/m^2 iv, d1, and carboplatin AUC .5 d1 , and the repeat courses were conducted with an interval 21 to 28 days. All the patients were evaluated for the response. RESULTS：The total response rate （CR＋PR） was 70.7%（CR=22, PR=19）. The side effects were mild, inclu ding myelosuppression, nausea and vomiting. CONCLUSIONS： The combination chemotherapy of docetaxel plus platinum is a safe and effective regimen for patients with recurrent ovarian carcinoma.
出处
《中华肿瘤防治杂志》
CAS
2008年第15期1176-1177,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
卵巢肿瘤/药物疗法
化疗
多帕菲
铂类
ovarian neoplasms /drug therapy
chemotherapy
doeetaxel
platinum
