摘要
目的:总结转化生长因子β(trans-forming growth facter-β,TGF-β)-Smad信号转导通路在大肠癌发生发展中研究的现状。方法:应用维普、万方及PubMed期刊全文数据库检索系统,以大肠癌、转化生长因子β和转导通路等为关键词,检索1993-01～2008-01相关TGF-β-Smad信号转导通路的文献。纳入标准:1)关于TGF-β-Smad信号转导通路具体转导步骤的研究。2)关于通路中各基因蛋白的结构作用的研究。3)关于TGF-β-Smad信号转导通路在大肠癌发生发展中作用的研究。4)关于通路在大肠癌治疗中所起作用的研究。粗选关于TGF-β-Smad信号转导通路方面的文章,根据纳入标准,精选54篇文献,最后纳入分析22篇文献。结果:TGF-β超家族是由一类结构和功能相关的多肽生长因子亚家族组成,广泛存在于多种生物的各种组织中,并在大肠癌细胞增殖分化、胚胎发生、血管形成和肿瘤发生中起重要作用,而通路中的其他因子也在大肠癌的发生发展中各自扮演不同的角色。结论:研究TGF-β信号通路的分子机制和Smads的功能与其他细胞因子之间的相互作用,及其在大肠癌中的特异性作用,对以信号通路作为靶点的大肠癌防治具有指导意义。
OBJECTIVE： To summarize the investigative status about the effect and significance of TGF-β/Smad pathway in the carcinogenesis and invasion of colorectal carcinoma. METHODS： The date was searched in VIP, Wanfangdata and PubMed from 1993-01 to 2008-01,with the key words of TGF-β, colorectal carcinoma and pathway. Internalize standardization; 1）the concrete procedure of TGF-β/Smad pathway. 2）research of various kinds gene and proteinum in TGF-β/Smad pathway. 3）research of effect and significance of TGF-β/Smad pathway in the carcinogenesis and invasion of colorectal carcinoma. 4） re search of effect of TGF-β/Smad pathway in treatment. After rough sizing, 54 literatures were sifed,but eventually 22 literatures were internalized. RESULTS： TGF-β superfamily is composed to a group of polypeptide growth factor which have homoioplastic framework and function. TGF-β superfamily generally exists in kind of creature and organism. It educes effect during hyperplasy and differentiation of cytes, development of embryo, formation of blood vessel and carcinogenesis of colorectal carcinoma. Simultaneously, other factors of TGF-β/Smad pathway act many roles in the carcinogenesis and invasion of colorectal carcinoma. CONCLUSION： Research of molecular mechanism of TGF-β/Smad pathway, function of Smads, effect between Smads and others factors and the specificity effect of TGF-β/Smad pathway in colorectal carcinoma is significant in the prevention and treatment of colorectal carcinoma.
出处
《中华肿瘤防治杂志》
CAS
2008年第15期1181-1184,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
肠肿瘤
转化生长因子
综述文献
intestinal neoplasms
transforming growth factor
review literature
