摘要
目的:探讨脑脊液细胞学检查联合癌胚抗原(CEA)免疫组化染色在脑膜癌病(Meningeal Carcinomatosis,MC)早期诊断中的应用价值。方法:脑脊液细胞学检查采用Shandon Cytospin4离心沉淀仪玻片离心法,CEA免疫细胞化学采用SP法。结果:33例经脑脊液细胞学检查均发现异常细胞,其中首次脑脊液细胞学检查阳性率为87.88%(29/33),22例结合CEA免疫组化染色,阳性率为81.82%(18/22);结论:脑脊液细胞学检查结合免疫细胞化学染色是诊断脑膜癌的重要手段,且两者互为补充。
Objective：To explore the early diagnostic value of cytologic examination of CSF combined with carcino-embryonic antigen immunocytochemistry examination in the patients with meningeal carcinomatosis.Methods：Thermo Electron Corporation Shandon cytospin 4 centrifuge was used in the cytologic examination of CSF,whose function is to produce a monolayer of cells onto a glass slide from CSF and SP staining method was used in the CEA immunocytochemistry.Results：There was a high positive rate in cytologic examination of CSF,malignant cells were found in all of 33 cases.The positive rate of routine cerebrospinal fluid cytologic examination for the first time were 87.88%（29/33）,The positive rate of 22 cases which combined with CEA immunocytochemistry examination was 81.82%（18/22）.Conclusion：Combining cytological with immunocytochemistry examination of CSF is a reliable earlier important diagnosing method for MC.The two methods are Complementary in the early diagnosis.
出处
《脑与神经疾病杂志》
2008年第4期322-325,共4页
Journal of Brain and Nervous Diseases
关键词
脑膜癌病
脑脊液
细胞学
免疫细胞化学
癌胚抗原
meningeal carcinomatosis cerebrospinal fluid（CSF） cytology immunocytochemistry CEA（carcino-embryonic antigen）
