摘要
目的探讨在小动物如兔蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)模型上经股动脉入路行选择性椎-基底动脉造影的可行性;探讨TCD对兔SAH后CVS状况的评价效度。方法采用枕大池2次注血法建立兔迟发性CVS的动物模型。术前1d和术后3、5d行选择性脑血管造影,判断CVS的程度;术前1d及术后1、3、5、7d行TCD连续检测基底动脉血流速度,从而判断CVS的变化及程度。结果在家兔CVS动物模型上成功完成左侧椎动脉选择性插管和造影,可有效地判断CVS的严重程度;采用TCD连续监测基底动脉血流速度可获得稳定图谱,能观察到制模后血流速度的变化情况。结论经兔股动脉入路行选择性椎-基底动脉造影是完全可行的,TCD可连续监测兔基底动脉血流速度,对兔SAH后CVS状况的评价稳定可靠,TCD与脑血管造影在检测SAH后CVS方面具有良好相关性。
Objective To validate the feasibility of the selective angiography of the vertebral-basal artery in cerebral vasospasm animal model after subarachnoid hemorrhage in rabbit via the transfemoral route and evaluate the diagnostic accuracy of Doppler ultrasound （TCD） in the assessment of cerebral vasospasm after subarachnoid hemorrhage in rabbits. Methods Vasospasm was induced in rabbits by the double injections of blood into the cisterna magna. The selective angiographies of the vertebral-basal artery were performed before and the 3 rd,5 th day after operation to detect cerebral vasospasm and TCD was used to assess the blood flow rate of basal artery before and the lst,3rd,5th,7th day after operation. Results The selective angiography of the vertebral-basal artery was successfully achieved in cerebral vasospasm animal model after subaraehnoid hemorrhage The high quality and intensity of basilar arterial TCD image was obtained and blood flow rate of the basal artery was assessed by improving frequency of ultrasound signal. Conclusions Selective angiography of the vertebral-basal artery in cerebral vasospasm animal model after subarachnoid hemorrhage can be obtained via the transfemoral route TCD is easy and accurate method to assess the blood flow rate of basal artery. There is a good correlation between TCD and DSA in assessment of the cerebral vasospasm after subarachnoid hemorrhage in rabbits.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2008年第7期397-401,共5页
Chinese Journal of Nervous and Mental Diseases
基金
山东省自然科学基金资助项目(编号:Y2006C45)
