摘要
目的:检测新生儿缺氧缺血性脑病(HIE)IgA、IgG、IgM及补体C3的变化,了解新生儿HIE对免疫功能的影响。方法:分别选择新生儿HIE 24例和8名正常新生儿作比较,采用免疫比浊法检测IgA、IgG、IgM和C3的血清水平。结果:新生儿HIE组与对照组比较,C3和IgG差异无统计学意义(P>0.05),而IgA和IgM差异均有统计学意义(P<0.01);轻度HIE组与中重度HIE组IgG差异有统计学意义(P<0.01),而IgA、IgM、C3差异均无统计学意义(P>0.05)。结论:新生儿HIE可使机体IgA、IgM水平下降,HIE病情与IgG有一定关系,对补体C3影响不大。
Objective：To study the influence of change of IgA, IgG, IgM and C3 on the immune function of the neonates with hypoxic ischemic encephalopathy（HIE）. Methods：Twenty-four cases of neonates HIE and eight controls were concluded in this study. Immuno turbidimetric method was used to detect the serum levels of IgA, IgG, IgM and C3 of the neonates, and the results were compared between the two groups. Results ： There was no statistical difference in C3 and IgG （ P 〉 0.05 ）, but IgM and IgA were significantly different between the two groups （P 〈 0.01 ） ;IgG showed statistical difference between the mild HIE group and the severe HIE group （P 〈 0.01 ） ,but there was no significant difference in IgA, IgM and C3 （P 〉 0.05 ）. Conclusions ：The IgA and IgM levels may decrease in the neonates HIE, HIE is related to IgG to some extent but is not related to C3.
出处
《蚌埠医学院学报》
CAS
2008年第4期427-428,共2页
Journal of Bengbu Medical College
关键词
婴儿
新生
疾病
脑缺氧
脑缺血
补体C3
免疫球蛋白类
infant,newborn,diseases
cerebral anoxia
cerebral ischemia
complement C3
immunoglobulins
