摘要
目的通过研究餐后高甘油三酯血症与血管内皮依赖性舒张功能、血管活性物质一氧化氮和颈动脉内—中膜厚度之间的关系,探讨老年糖尿病人餐后脂代谢紊乱对血管内皮功能的影响。方法选取空腹血脂正常的老年2型糖尿病患者26例和健康体检者10例进行脂肪餐试验,糖尿病组根据餐后4h甘油三酯是否大于2.0mmol/L分为餐后正常组和餐后增高组,测各时间点血清甘油三酯、一氧化氮和内皮素1水平,高分辨超声检测血管内皮依赖性舒张功能及颈动脉内—中膜厚度。结果餐后正常组和餐后增高组餐后4h甘油三酯差异有显著性(P<0.05),各组一氧化氮、内皮素1与血管内皮依赖性舒张功能及颈动脉内—中膜厚度呈正相关。结论老年糖尿病患者存在餐后脂代谢紊乱,它可导致血管内皮功能受损,促进动脉粥样硬化的发生发展。
Aim To assess the effect of postprandial triglyceride and serum level of NO, ET- 1 on the endothelial function in elderly type 2 diabetic patients. Methods Subjects were assigned to two groups： the observed group of 26 fasting normotriglyceridemic elderly type 2 diabetic patients who were divided into two subgroups： subgroup 1 [4 hour postprandial blood trig- lyceride level （TG≤2.0 mmol/1） ] and subgroup 2 （TG 〉 2.0 mmol/1） according to the level of TG ＋ 2S in control group; the healthy control group of 10 normal subjects. Total triglyceride（TG）.NO.ET-1 were measured before and 2, 4 and 6 hours after a fatty meal （600 kcal, 56%fat, 6.5%protein, 37.5%carbohydrate）. Carotid IMTc.fasting FMD and 4h after the meal were measured by ultrasonography. Results 2, 4, 6 hours after a fatty meal, there was a slightly postprandial rise of TG and sig- nificant differences in TG4h between the observed group and healthy controls （ P 〈 0.05 ）. NO/ET- 1 was positively correlated with FMD and IMTc. Conclusion There are postprandial triglyceride metabolic disturbance in the elderly diabetes, which leads to compensate increasing production of NO and moment descendent of ET-1 level. The disturbance of the equilibrium be- tween TG and NO, ET-1 which induced endothelial dysfunction may be correlated with diabetic angioplasty.
出处
《中国动脉硬化杂志》
CAS
CSCD
2008年第4期303-306,共4页
Chinese Journal of Arteriosclerosis
基金
山东省科技发展计划基金项目(2005GG4202007)
关键词
内科学
2型糖尿病
脂代谢紊乱
内皮
血管
一氧化氮
内皮素
Diabetes MeUitus
Hypertriglyceridemia
Endothehum, Vascular
Nitric Oxide
Endothelin-1 [
