摘要
目的研究比阿培南在健康受试者体内的药动学过程。方法20名健康受试者(男女各10名)随机分为2组,分别单剂量(0.3 g)和多剂量(0.3 g×9)静脉滴注(静滴)比阿培南后,采用高效液相色谱法测定血浆中比阿培南浓度。用DAS(ver 2.0.1)药动学软件进行房室模型判断并计算药动学参数。结果比阿培南的体内经时过程符合二房室模型,单剂量和多剂量静滴比阿培南后,t_(1/2)分别为(1.04±s 0.09)和(1.03±0.11)h;c_(max)分别为(18±4)和(16.1±2.9)mg·L^(-1);A UC_(0～6)分别为(26±5)和(24±4)mg·h·L^(-1);多剂量c_(as-cav)为(2.0±0.3)mg·L^(-1),c_(as-min)为0 mg·L^(-1)。结论比阿培南的体内经时过程符合二房室模型,每日2次,连续静滴比阿培南9次后,体内药物没有蓄积。
AIM To investigate the pharmacokinetics process of biapenem following a single and multiple doses intravenous administration in healthy volunteers. METHODS Twenty healthy volunteers （10 males, 10 females） were divided into two groups randomly, and received a single dose （0.3 g, iv, gtt） and multi-dose （0.3 g × 9, iv, gtt） of biapenem drip infusion. Blood samples of 3 mL each time individually were collected from antecubital vein at certain planned times. Biapenem concentration in plasma was determined by HPLC method, and the pharmacokinetic parameters were calculated and determined by DAS software. RESULTS The intracorporeal passing process of biapenem coincided with two-compartment mode. The single dose and multi-dose pharmacokinetic parameters were as follows： t1/2 （1.04 ± s 0.09） and （1.03 ± 0.11） h, cmax （18 ± 4） and （16.1 ± 2.9） mg·L-1, AUC0-6 （26 ± 5） and （24 ± 4） mg·h·L-1, respectively. The multi-dose css-caw, was （2.0 ± 0.3） mg·L-1. CONCLUSION The plasma concentration-time curves of biapenem were fitted to a two-compartment mode with no accumulations in vivo after multi-dose infusion （0.3 g ×9, iv, gtt）.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2008年第7期500-503,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
比阿培南
色谱法
高压液相
药动学
biapenem
chromatography, high pressure liquid
pharmacokinetics
