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内皮祖细胞与氧化应激 被引量：7

Endothelial Progenitor Cells and Oxidative Stress
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摘要 内皮祖细胞(endothelial progenitor cells,EPCs)是成熟内皮细胞的前体细胞,参与损伤组织的血管新生和再内皮化。研究表明,氧化应激能引起EPCs的数量减少和功能减弱。虽然EPCs存在抗氧化酶系统,但是当细胞正常的氧化还原稳态失衡时,活性氧过度产生而聚积,引起氧化应激,导致细胞的衰老或凋亡。 Endothelial progenitor cells （EPCs） are the precursors of mature endothelial cells and are involved in neovascularization and reendothelization. Previous studies have shown that oxidative stress can reduce the number of EPCs and impair the function of EPCs. Although EPCs possess their antioxidative enzymes, an oxidative stress may still occur, when redox homeostasis is disturbed and reactive oxygen species （ROS） is excessively accumulated, which leads to cellular senescence or apoptosis.
作者 赵婷 黎健
机构地区 卫生部北京医院老年医学研究所卫生部老年医学重点实验室
出处 《医学分子生物学杂志》 CAS CSCD 2008年第4期344-347,共4页 Journal of Medical Molecular Biology
基金 国家重点基础研究发展规划项目(973计划)(No.2006CB503910) 国家自然科学基金(No.30572082) 北京自然科学基金(No.7052059)~~
关键词 内皮祖细胞 氧化应激 抗氧化酶 凋亡 衰老 endothelial progenitor cells oxidative stress antioxidative enzymes apoptosis senescence
分类号 R345 [医药卫生—基础医学]
  • 相关文献

参考文献24

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二级参考文献10

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共引文献13

同被引文献119

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  • 2叶健华,马承红,周斌兵,钟亮尹,周昭远,林晓峰,严励.血管内皮生长因子在早期糖尿病微血管病变中的变化及意义[J].广东药学院学报,2006,22(2):197-198. 被引量：10
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引证文献7

二级引证文献13

医学分子生物学杂志
2008年 第4期

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