摘要
目的:对比宫颈癌术后同步放化疗和化疗+放疗+化疗交替治疗的毒性、依从性和近期疗效,探索宫颈癌术后同步放化疗的可行性。方法:自2003年1月至2007年6月,行广泛全宫切除+盆腔淋巴结清扫的Ⅰ_(b1)-Ⅱ_b期宫颈癌,术后病理提示有肿瘤复发高危因素,拟行术后辅助治疗者,随机分成A、B两组,各30例,A组同步放化疗,B组采用化疗+放疗+化疗交替治疗,对比两组患者治疗过程中的体重下降、骨髓抑制、胃肠道反应、肝肾毒性、皮肤反应、膀胱毒性、直肠毒性等急性放化疗反应的程度和患者的依从性,观察近期疗效。结果:两组治疗过程中的骨髓抑制、胃肠道反应、肝肾毒性、皮肤反应、膀胱反应、直肠反应程度相近,重度毒性反应发生率比较,无统计学差异,均无由于毒副反应无法耐受而终止治疗者。随访期内,A组2例发生远处转移,均已死亡,B组2例发生腹主动脉旁淋巴结转移,1例死亡,1例挽救治疗中;两组肿瘤控制率相近。结论:宫颈癌术后同步放化疗并不明显加重毒副反应,治疗依从性好,近期疗效满意。宫颈癌术后同步放化疗是可行的。
Objectives：To compare the treatment toxicity, compliance, and short -term outcome of cervical carcinoma treated with postoperative concurrent radiochemotherapy and in - turn treatment with chemo - radio - chemo- therapy and to explore the feasibility of postoperative concurrent radiochemotherapy for ⅠbI-Ⅱb cervical carcinoma. Methods：From 2003 through 2007, 60 patients with FIGO stage ⅠbI-Ⅱb cervical carcinoma treated with extensive hysterectomy plus pelvic dissection who were proven with high risk pathologic factors and adjuvant radiotherapy required were enrolled in the study and randomized divided into 2 groups, equally 30 cases in each group. Group A were treated with concurrent radiochemothcrapy, while group B were treated with chemo - radio - chemotherapy. Weight lost, marrow suppress, acute toxicity of gastrointestinal, liver, kidney, skin, bladder, and rectum, as well as treatment compliance and short - term tumor control of the two groups were compared. Results： Weight lost, marrow suppress, acute toxicity of gastrointestinal, liver, kidney, skin, bladder, and rectum reactions were comparable be- tween two groups. No case dropped out due to unendurable treatment toxicity. Within follow - up period, 2 cases died of distant metastasis in group A. 2 cases in group B had para - aortic lymph node metastasis, 1 died, while the other case is receiving salvage treatment. Conclusion：Acceptable toxicity, satisfying treatment compliance and short -term tumor outcome suggest that postoperative concurrent radiochemotherapy is feasible for cervical carcinoma.
出处
《现代肿瘤医学》
CAS
2008年第8期1378-1380,共3页
Journal of Modern Oncology
关键词
宫颈癌
同步放化疗
Ⅰ期临床研究
cervical carcinoma
concurrent radiochemotherapy
phase I clinical study
