摘要
目的研究吸入激素对稳定期支气管扩张症患者咳嗽、咳痰及痰中白细胞介素6(IL-6)、白细胞介素8(IL-8)、中性粒细胞表达的影响。方法30例支气管扩张症患者,吸入氟替卡松500μg,每日2次,共4周,观察治疗前后咳嗽、咳痰改善情况;用酶联免疫吸附试验法测定治疗前后痰中IL-6、IL-8、中性粒细胞水平。选取性别、年龄相匹配的30例健康人为正常对照。结果支气管扩张症患者痰中IL-6、IL-8、中性粒细胞水平均明显高于正常对照组(P<0.01),吸入氟替卡松治疗4周后咳嗽好转,痰量减少。痰中IL-6、IL-8、中性粒细胞水平较前明显降低(P<0.01),仍高于正常对照组(P<0.01)。结论IL-6、IL-8、中性粒细胞在支气管扩张症的病理生理过程中起着重要作用,吸入氟替卡松可降低痰中IL-6、IL-8、中性粒细胞的含量,减轻炎症反应。
Objective To investigate the effect of inhaled corticosteroid on the expression of interleukin-6 （IL-6）,interleukin-8 （IL-8） and neutrophils in sputum from patients with bronchiectasis.Methods The 30 patients with bronchiectasis received 500 μg of fluticasone,two times a day for 4 weeks.During the study,the symptom of cough,and the amount and nature of sputum were recorded.Neutrophil proportion in induced sputum were examined.The levels of supernatant interleukin-6,interleukin-8 of sputum were detected by ELISA both before and after treatment in patients as well as in 20 normal controls.Results Before the treatment,the sputum levels of interleukin-6 and interleukin-8 and neutrophil proportion were significantly higher in the patients than those in the controls （P〈0.01）.After four weeks of treatment,though the levels dropped markedly （P〈0.01）,they remained higher than those in the controls （P〈0.01）.Patients have had the reduction of sputum and cough alleviation.Conclusion Neutrophils,interleukin-6 and interleukin-8 play an important role in the pathophysiologic process of bronchiectasis.Inhaled corticosteroid can control inflammation through the reduction of neutrophils,interleukin-6 and interleukin-8.
出处
《临床肺科杂志》
2008年第9期1120-1121,共2页
Journal of Clinical Pulmonary Medicine
