摘要
目的：研究近年来颌骨放射性骨坏死（ＯＲＮＪ）病例的临床和病理特点，为进一步提高防治水平提供参考。方法：对１９９１年以来我科收治的２６例ＯＲＮＪ病例就临床表现和病理特点诸方面进行总结分析。结果：半数以上病例照射总剂量超过８０Ｇｙ，２３例（８８．４％）有明确创伤感染史。组织病理学检查反映出ＯＲＮＪ病变时期下牙槽动脉并未闭塞，病变四周的骨髓腔内仍可见活跃的新骨生成，毛细血管增殖。结论：高剂量放射是当前临床ＯＲＮＪ发病的显著特点，创伤与感染仍是ＯＲＮＪ发病的重要因素。组织病理学检查结果进一步解释了一些诸如Ｘ线检查、核素骨显像上ＯＲＮＪ病灶及周围密度增高影、放射线浓聚等重要临床征象。
OBJECTIVE:The clinicopathologic characteristics of recent-year ORNJ (Osteoradionecrosis of jaws)were studied so as to provide useful data for its prevention and treatment. METHOD:The medical records of 26 case ORNJ were summed up and analysed from aspect of clinical and pathologic manifestation. RESULT:Over half number of the patients had received the radiation with total dose exceeding 80Gy;23 cases(88.4%)had a specific history of trauma and infection;In histopathologic examinations,not only did inferior alveolar arteries remain patency,but active new bone formation and capillary proliferation could be seen in the medullas around the necrotic lesions. CONCLUSION:High-dose irradiation was a prominent feature of current ORNJ cases;Both trauma and infection were important etiological factors.The histopathologic findings gave further explanation for some clinical phenomena such as high density image around ORNJ lesion in X-ray film and increased uptake in bone scan.
出处
《口腔颌面外科杂志》
CAS
1997年第3期157-161,共5页
Journal of Oral and Maxillofacial Surgery
基金
上海市高教局博士点基金
