摘要
[目的]观察单纯放疗和同期放化疗两种治疗方法对局部晚期鼻咽癌的临床疗效、毒副反应。[方法]将56例T3～4N3M0鼻咽癌病人随机分为单纯放疗组(对照组)和同期放化组(放化组)各28例。放疗:两组病人均使用常规分割外照射,使鼻咽部剂量达到70～78Gy,颈部剂量达到66～80Gy。化疗:放化组采用顺铂、氟尿嘧啶(5-Fu),1次/周,共用3～6个周期。[结果]对照组28例病人均按计划完成治疗,放化组中有6例病人因严重放化疗反应未能按计划完成。对照组和放化组3年生存率分别为71.42%、75.00%(P>0.05);3年远处转移率分别为28.57%、25.00%(P<0.05);3年累计复发率分别为14.28%、17.85%(P>0.05);3年无瘤生存率分别为67.85%、64.28%(P<0.05)。[结论]局部晚期鼻咽癌顺利完成同期放化疗的患者,远处转移率及无瘤生存率体现一定的优势。
[Purpose] To investigate the response and toxicity of radiotherapy alone and concurrent chemoradiotherapy for local advanced nasopharyngeal cancer. [Methods ] Fifty-six cases with T3-4N3M0 naso pharyngeal cancer were randomly divided into radiotherapy alone group （control group ） and concurrent chemoradiotherapy group （CR group）. Radiotherapy： conventional division external irradiation, enabled the nasopharynx department dosage to achieve 70-80Gy and the pate dosage achieves 66-80Gy for both groups; Chemotherapy： the platinum（DDP）, 5-fluorouracil（5-Fu） once a week for 3-6 cycles for CR group. [Results] Twenty-eight cases in control group completely endured the treatment scheme while 6 cases in CR group discontinued chemotherapy because of severe toxicity. The 3-year survival rates in control group and CR group were 71.42%, 75%（P〉0.05）; 3-year distant metastasis rates were 28.57%, 25.00%（P〈0.05）;3-year accumulated recurrence rates were 14.28%,17.85%（P〉0.05）; 3-year tumor-free survival rates were 67.85%,64.28%（P〈0.05）, respectively. [Conclusion] Concurrent chemoradiotherapy has demonstrated superiority of reducing distant metastasis and increasing tumor-free survival in patients with local advanced nasopharyngeal cancer who completes the concurrent chemoradiotherapeutic regimen.
出处
《中国肿瘤》
CAS
2008年第8期736-738,共3页
China Cancer
关键词
鼻咽肿瘤
同步放化疗
顺铂
氟尿嘧啶
生存率
毒副反应
nasopharyngeal neoplasms
concurrent chemoradiotherapy
platinum
fluorouracil survival rate
toxicity
