摘要
目的：评价尿白介素６（ＩＬ－６）检测在狼疮性肾炎（ＬＮ）病情判断中的价值。方法：应用特异性酶联免疫吸附法检测５８例ＬＮ患者血清、尿ＩＬ－６含量。结果：各型ＬＮ患者尿ＩＬ－６含量均明显升高，其中隐匿型尿ＩＬ－６含量已有明显升高，肾功能不全型尿ＩＬ－６含量显著高于隐匿型、肾炎型或肾病综合征型。活动期ＬＮ患者尿ＩＬ－６含量显著高于非活动期，经治疗后明显降低，复发时重新升高。ＷＨＯⅣ型ＬＮ患者尿ＩＬ－６含量明显高于其他病理类型。此外，尿ＩＬ－６含量与血清ＩＬ－６含量不相关，但与抗ｄｓＤＮＡ抗体相关。结论：尿ＩＬ－６含量在ＬＮ病情活动、治疗、复发过程中及不同临床分型与病理分型中的改变，提示尿ＩＬ－６检测可作为ＬＮ早期诊断、活动性监测、疗效及复发判断的非创伤性生化指标之一，并可部分替代肾活检。
OBJECTIVE To evaluate the clinical value of detection of urinary interleukin6 (IL6) in patients with lupus nephritis (LN).METHODOLOGY 58 LN patients (female to male 55/3,aged 291±56) were included in this prospective clinical trial. According to the clinical manifestations, they were divided into four types, either in active or in inactive stages. 25 of 42 cases with active LN had received renal biopsy. Urinary level of IL6 was measured by enzymelinked immunosorbent assay.RESULTS Urinary IL6 level in LN patients was significantly higher than that in normal controls (P<001). In 42 cases of active LN, urinary IL6 concentrations, higher than that in 16 cases of inactive LN (P<005), were decreased obviously after treatment, but remained within abnormal levels (P<001). There was a rapid increase during relapse period in three consecutive patients who developed an exacerbation after remission. Urinary IL6 levels in LN patients with renal insufficiency were significantly higher than that in LN patients without (P<005). Urinary IL6 concentrations in patients histologically diagnosed as WHO class 4 were significantly higher than that in patients with other classes (P<0001). In addition, Urinary IL6 level did not correlate with serum IL6 level, but with serum antiDNA antibody.CONCLUSION The measurement of urinary IL6 may be a valuable tool for monitoring the progression or exacerbation of lupus nephritis and it can be used to partly replace the renal biopsy.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1997年第5期426-429,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
