摘要
目的研究三七[Panaz notoginseng(Burk.)F.H.Chen]芦头总皂苷酸降解产物的化学成分。方法利用硅胶柱色谱、高效液相色谱、重结晶等方法进行分离纯化,并根据化合物的理化常数和光谱数据进行结构鉴定。结果从三七芦头总皂苷酸降解产物中分离得到7个化合物,分别鉴定为20(S)-人参二醇(PD,I)、20(R)-原人参二醇(PPD,Ⅱ)、20(S)-人参三醇(PT,Ⅲ)、20(S)-25-甲氧基-达玛烷-3β,12β,20-三醇[20(S)-25-OCH3-PPD,Ⅳ]、20(R)-原人参三醇(PPT,V)、20(R)-达玛烷-3β,12β,20,25-四醇(25-OH—PPD,Ⅵ)、20(R)-达玛烷-3β,6a,12β,20,25-五醇(Ⅶ)。结论化合物I~Ⅶ均为从三七芦头总皂苷酸降解产物中首次分得。
Aim To study the chemical constitutents of acid hydrolysate of saponins from the basal part of stem of Panax notoginseng. Methods The constitutents were isolated and purified by chromatography on silica gel and HPLC chromatogtaphy and recrystallization. Their structures were elucidated on the physicochemical properties and spectral analysis. Results Seven constitutents were identified as 20 ( S )-panaxadiol (PD, I ), 20 ( R )-protopanaxadiol ( PPD, Ⅱ ), 20 ( S )-panaxotriol ( PT, Ⅲ ), 20 ( S )-25-methoxyl-dammarane-3β, 12β, 20-triol (20 ( S )-25-OCH3-PPD, 1V ), 20 ( R )-protopanaxtriol ( PPT, V ), 20 ( R )- dammarane-3β, 12β, 20, 25-tetrol(25-OH-PPD, Ⅵ ), 20 ( R )-dammarane-3β, 6α, 12β, 20, 25-pentolⅦ ). Conclusion I - Ⅶ were isolated from the basal part of stem of Panax notoginseng for the first time.
出处
《中国药物化学杂志》
CAS
CSCD
2008年第4期288-290,299,共4页
Chinese Journal of Medicinal Chemistry
关键词
三七芦头
酸降解产物
化学成分
the basal part of stem of Panax notoginseng
hydrolysate
chemical constituent