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Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis 被引量：4

Cerebral venous thrombosis and heparin-induced thrombocytopenia in an 18-year old male with severe ulcerative colitis
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摘要 The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia (HIT). The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor . The risk of thromboembolism is increased in inflammatory bowel disease and its symptoms may be overlooked. Furthermore, its treatment can be complex and is not without complications. We describe a case of an adolescent boy who developed a cerebral sinus venous thrombosis during a relapse of his ulcerative colitis and who, while on treatment with heparin, developed heparin-induced thrombocytopenia （HIT）. The treatment was then switched to fondaparinux, a synthetic and selective inhibitor of activated factor Ⅹ.
作者 Gudrun Scheving Thorsteinsson Maria Magnussson Lena M Hallberg Nils Gunnar Wahlgren Fredrik Lindgren Petter Malmborg Thomas H Casswall
机构地区 Department of Pediatrics Pediatric Coagulation Unit Division of Radiology Clinical Neuroscience Unit Division of Paediatric Gastroenterology
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第28期4576-4579,共4页 世界胃肠病学杂志（英文版）
基金 The Swedish Order of Freemasons
关键词 Inflammatory bowel disease Ulcerative colitis Cerebral venous thrombosis Heparin-induced thrombocytopenia FONDAPARINUX 炎症肠炎 肠溃疡 静脉血栓形成 老年
分类号 R574.62 [医药卫生—消化系统]
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参考文献13

  • 1F. Masuhr MD,S. Mehraein.Cerebral venous and sinus thrombosis[J].Neurocritical Care.2004(3)
  • 2Lorenz Risch,Joachim E. Fischer,Roberto Herklotz,Andreas R. Huber.Heparin-induced thrombocytopenia in paediatrics: clinical characteristics, therapy and outcomes[J].Intensive Care Medicine.2004(8)
  • 3Shelley Renowden.Cerebral venous sinus thrombosis[J].European Radiology.2004(2)
  • 4Sands BE.Immunosuppressive drugs in ulcerative colitis: twisting facts to suit theories?[].Gut.2006
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  • 6Manco-Johnson MJ.How I treat venous thrombosis inchildren[].Blood.2006
  • 7Risch L,Fischer JE,Herklotz R,Huber AR.Heparin- induced thrombocytopenia in paediatrics: clinical characteristics, therapy and outcomes[].Intensive Care Medicine.2004
  • 8Hasegawa H,Yokomori H,Tsuji T,Hirose R.Hemorrhagic cerebral sinus thrombosis in a case of controlled ulcerative colitis[].Journal of Internal Medicine.2005
  • 9Hasan Umit,Talip Asil,Yahya Celik,Ahmet Tezel,Gulbin Dokmeci,Nermin Tuncbilek,Ufuk Utku,Ali Riza Soylu.Cerebral sinus thrombosis in patients with inflammatory bowel disease: A case report[J].World Journal of Gastroenterology,2005,11(34):5404-5407. 被引量：6
  • 10Twig G,Zandman-Goddard G,Szyper-Kravitz M,Shoenfeld Y.Systemic thromboembolism in inflammatory bowel disease: mechanisms and clinical applications[].Annals of the New York Academy of Sciences.2005

二级参考文献37

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共引文献5

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引证文献4

二级引证文献12

World Journal of Gastroenterology
2008年 第28期

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