摘要
术后认知功能障碍(POCD)是指术后人格、社交能力及认知能力和技巧的变化。在老年人中发生率较高,一定程度上影响其术后生活质量,本文就老年人POCD的定义、发病率、发病机制、可能的发病原因、诊断标准等方面进行综述。目前对于影响POCD的主要因素和次要因素尚有争论,发病机制方面也存在众多未知的领域,ApoE基因的特异性还不强,需寻找更理想的基因预警指标。研究POCD具有重要的医学和社会意义。
The definition of postoperative cognitive dysfunction（POCD） refers to memory loss and lack of concentration that occur in patients who have undergone a surgical procedure. It occurs frequently in the elderly patients ,which is a severe and life-threatening complication after an operation. This article reviews the definition, epidemiology, pathophysiologic mechanisms, etiology, and psychological tests used for diagnosis of POCD. At present,the main factors and secondary factors affecting POCD is still under controversy,what＇s more ,there is also many unknown domain in its etiology. The ApoE gene has no better specificity,it is necessary to seek for more ideal gene marker indicating this disease. It has great social and medical significance to study POCD.
出处
《医学综述》
2008年第16期2473-2475,共3页
Medical Recapitulate
关键词
术后认知功能障碍
老年人
麻醉
Postoperative cognitive dysfunction
Elderly
Anesthesia
