摘要
采用体外培养的大鼠主动脉血管平滑肌细胞（ＶＳＭＣ）为模型，测定其脂质过氧化物（ＬＰＯ）含量，观察精氨酸加压素（ＡＶＰ）对ＶＳＭＣ脂质过氧化的影响和辅酶Ｑ１０（ＣｏＱ１０）的干预作用。结果显示：（１）ＡＶＰ有明显的促ＶＳＭＣ脂质过氧化作用（Ｐ＜０．０１），且时间愈长，作用愈显著。（２）ＣｏＱ１０对ＡＶＰ的促ＬＰＯ生成有明显的降低作用（Ｐ＜０．０１），并随浓度增高作用增强。此提示ＡＶＰ参与高血压发病可能与其促ＶＳＭＣ脂质过氧化作用有关；ＣｏＱ１０具有拮抗ＡＶＰ促ＶＳＭＣ脂质过氧化作用，这对高血压病的防治将有意义。
The purposes of the present study were to evaluate the effects of arginine vasopressin (AVP) on lipid peroxide (LPO) of vascular smooth muscle cell (VSMC) and the effects of coenzyme Q_10(CoQ_10). The cultured aorta VSMC of rats was used to detect the content of LPO and investigate its change in VSMC induced by AVP and its regulation by CoQ10. The results showed that: (1) AVP significantly enhanced the production of LPO in VSMC (P<0.01). This effect became more apparent with the time; (2) CoQ10 significantly inhibited the effect of LPO production of VSMC induced by AVP (P<0.01). This action became more apparent with the increase of CoQ10 level. It is concluded that AVP might be involved in the hypertension by enhancing LPO production of VSMC; CoQ_10 could inhibit this effect, which would have important role in preventing and treating hypertension.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1997年第6期457-459,共3页
Chinese Journal of Cardiology
