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ABCB11基因在妊娠期肝内胆汁淤积症中研究进展 被引量：1

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摘要 ABCB11基因,也称BSEP基因,其编码的蛋白称为ABCB11蛋白,是ABC转运蛋白超家族B族成员之一。ABCB11基因的表达主要受法尼醇X受体(FXR)调控。近年研究发现,一些药物或体内的代谢产物等对ABCB11基因的调控及由基因变异等因素引起的相关蛋白功能障碍,可能在妊娠期肝内胆汁淤积症(ICP)发病中发挥重要作用,并且ABCB11基因有可能成为靶基因而作为ICP基因治疗的一种手段。
作者 杜永江 吕时铭 姚琦玮
机构地区 浙江大学医学院附属妇产科医院
出处 《国际妇产科学杂志》 CAS 2008年第4期291-293,共3页 Journal of International Obstetrics and Gynecology
关键词 ABCB11 变异 非遗传因素 基因治疗 妊娠期肝内胆汁淤积症
分类号 R714.2 [医药卫生—妇产科学]
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共引文献19

同被引文献21

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国际妇产科学杂志
2008年 第4期

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