摘要
目的探讨重度子痫前期患者孕中期血清人绒毛膜促性腺激素(β-hCG)和甲胎蛋白(AFP)的变化及其临床意义。方法选取66例重度子痫前期患者为研究组,其中13例早发型重度子痫前期患者为早发组,53例晚发型重度子痫前期患者为晚发组,并选取同期128例正常妊娠者为对照组。测定研究组发病前孕中期的血清β-hCG和AFP的水平,并与对照组进行比较。结果重度子痫前期组、早发组、晚发组及对照组的血清β-hCG水平间差异有统计学意义(P<0.05),其中重度子痫前期组、早发组、晚发组与对照组间差异均有统计学意义(P<0.05),早发组与晚发组间差异无统计学意义(P>0.05);重度子痫前期组、早发期、晚发期及对照组的AFP间差异无统计学意义(P>0.05)。结论重度子痫前期患者发病前血清β-hCG水平升高,对重度子痫前期有一定预测意义;AFP水平无变化,其在重度子痫前期的变化及其预测意义有待于进一步探讨。
Objective To investigate the changes and their clinical significance of serum levels of β- human chorionic gonadotrophin （ β - hCG） and α - fetoprotein （AFP） in the 2nd trimester in patients with severe preeclampsia. Methods Atotal of 66 severe preeclampsia patients in the 2nd trimester （ 13 early onset preeclampsia patients and 53 late onset preeclampsia patients ） were enrolled as the trial group and 128 normal pregnant women in the same trimester were enrolled as the controls. The levels of serum β - hCG and AFP before onset were measured and compared with those in the control group. Results β - hCG levels in serum were significantly elevated in women in both early and late onset preeclampsia groups as compared with that in the control group （ P 〈 0. 05 ）, but there was no significant difference between early onset preeclampsia group and late onset preeclampsia group （ P 〉 0. 05）. There was no significant difference in serum AFP level among all the groups （ P 〉 0. 05）. Conclusion β - hCG levels in serum of severe preeclampsia patients increases in the 2nd trimester, and it has a certain predictive significance to severe preeclampsia. Serum AFP level has not obvious change in severe preeclampsia, and its change and predictive significance remain to be studied.
出处
《中国全科医学》
CAS
CSCD
2008年第17期1531-1532,1535,共3页
Chinese General Practice
基金
国家自然科学基金资助项目(30530760)
