摘要
目的检测基质金属蛋白酶(MMP-2和MMP-9)与乳腺癌的淋巴结转移、病理分级、患者年龄及肿瘤大小之间的可能关系,及对术后的影响。方法65例乳腺癌蜡块,采用免疫组化S-P法染色,以细胞浆中有棕色颗粒计数分为:阴性;弱阳性;中度阳性及强阳性。结合随访材料进行统计分析。结果MMP-2和MMP-9的表达与乳腺癌患者的年龄及肿瘤大小无关;MMP-2与淋巴结转移有关,无淋巴结转移者,MMP-2表达较低;有淋巴结转移者,MMP-2表达较高。MMP-9的表达与淋巴结转移情况则无关。MMP-2和MMP-9的表达与病理分级相关。二者均影响预后,MMP-2低表达组术后10年生存率为100%,MMP-2高表达组术后1、3、5及10年生存率分别为100%、86.11%、75.0%、66.67%,两组间有显著性差异(P(0.01);MMP-9低表达组术后10年生存率为100%,MMP-9高表达组术后1、3、5及10年生存率分别为100%、86.49%、72.97%、64.86%,两组间有显著性差异(P(0.01)。结论MMP-2和MMP-9的表达与乳腺癌病理学分级有关;MMP-2与淋巴结转移有关,而MMP-9与淋巴结转移无关。二者高表达生存率均降低,影响预后。
Objective To examine the expression of MMP-2,MMP-9 and their relationship with the lymphnode metastasis, pathological grade, tumor size,the age of patient of breast cancer and the survival probability. Methods Sixty-five cases of breast cancer, all patients were female, no chemotherapy and radiotherapy before operation. Immunohistoehemieal staining method of S-P was used to examine the positivity of MMP-2 and MMP-9. Results The positivity of MMP-2 is associated with lymphnode metastasis, pathological grade while the positivity of MMP-9 has no relationship with lymphnode metastasis, the positivity of MMP-2 and MMP-9 have no relationship with tumor size and the age of patient. The high level of MMP-2 and MMP-9 was associated with the low survival probability. The 1-year, 3-year,5-year and 10- year survival rate of the positivity of MMP-2 was 100% ,86.11% ,75.0% and 66.67% respatively while the 10-year survival rate of the negative MMP-2 was 100% （P 〈 0.01）. The 1-year,3-year, 5-year and 10-year survival rate of the positivity of MMP-9 was 100% , 86.49% , 72.97% and 64.86% respatively while the 10-year survival rate of the negative MMP-9 was 100% （P 〈 0.01）. Conclusion The positivity of MMP-2 and MMP-9 are connected with predictive information of breast cancer.
出处
《实用肿瘤学杂志》
CAS
2008年第4期331-334,357,共5页
Practical Oncology Journal
