摘要
苯为确认的人类致癌物,可引起非淋巴细胞性白血病等一系列血液系统的损害,但其血液毒性机制至今仍不十分明确。本文就苯的代谢活化、苯及其代谢物的细胞毒性、遗传毒性及该领域的相关方法学研究进展作一综述。
Benzene is a well-known human carcinogen and can cause acute nonlymphocytic leukemia and a variety of blood disorders, such as preleukemia and aplastic anemia, however the mechanism still remains unclear. This paper will give a general introduction on the latest progress in the metabolism, cytotoxicity, genotoxicity of benzene and its metabolites, and concerned methodological studies in this field.
出处
《中国工业医学杂志》
CAS
北大核心
2008年第4期247-250,共4页
Chinese Journal of Industrial Medicine
基金
浙江省自然科学基金资助项目(Y207394)
关键词
苯
代谢活化
细胞毒性
遗传毒性
Benzene
Metabolic activation
Cytotoxicity
Genotoxicity
