摘要
栓塞材料的选择在脑动静脉畸形的治疗中起着十分重要的作用。α-氰基丙烯酸正丁酯是最常用的黏附性液体栓塞材料,其在脑动静脉畸形栓塞治疗中的弥散性能良好,聚合速度可控制,但α-氰基丙烯酸正丁酯容易将导管粘连在血管壁上,导致严重的并发症。非黏附性液体栓塞材料Onyx和醋酸纤维素聚合物具有不易粘连导管、容易操作等特性,二者都在二甲基亚砜中沉淀析出达到栓塞目的,二甲基亚砜具有明显的毒性及很强的腐蚀性,可以导致栓塞血管痉挛和内皮坏死。新型液体栓塞材料CoHEMA和阳性离子聚合物EudragitE无细胞毒性,黏度低,容易通过微导管输送,栓塞效果稳定。甲基丙烯酸共聚物大多以乙醇为溶剂,容易造成对血管的损害,无毒且能溶于水的非黏附性液体栓塞材料是目前研究的主要目标。
The selection of embolization materials plays an important role in the treatment of cerebral arteriovenous malformation. Butyl- a -cyanoacrylate is the most adhesive fluid embolization material with good diffusibility and controlled polymerization. But it is prone to attach on the wall of blood vessels and induce serious complications. Non-adhesive fluid embolization materials, such as Onyx and cellulose acetate polymer are free from the adhesion and easy to operate. Both of them could precipitate from the dimethyl sulphoxide, which exhibits strong toxicity and causticity, thus resulting in vasospasm and endothelial apoptosis. Neotype fluid embolization material CoHEMA and positive ionic polymer Eudragit E have no cytotoxicity and low viscosity, so they are easy to transport through the micro-tube and achieve stable embolization. Taking alcohol as a solvent, methacrylic acid copolymer induces the vascular damage, so the non-toxic and water-soluble non-adhesive fluid embolization materials are promising to be investigated.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第27期5321-5324,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
