摘要
目的比较国产无细胞百白破疫苗与进口无细胞百白破疫苗接种反应差异。方法2007年1～8月在广州市天河区中医院接种门诊接种的3个月以上、2岁以内的儿童1230名,向家长介绍两种疫苗的免疫原性和安全性,让家长自愿选择其中一种疫苗接种。接种后24～48h观察局部反应和全身反应。结果725名接种国产无细胞百白破疫苗儿童有局部反应84例,反应率为11.59%;全身反应108例,反应率为14.90%。505名接种进口无细胞百白破疫苗儿童有局部反应29例,反应率为5.74%;全身反应41例,反应率为8.12%。其中两组的第一、二、三针的局部反应和全身反应的差异没有统计学意义,第四针的局部反应和全身反应的差异有统计学意义。接种进口无细胞百白破疫苗第四针的全身反应和局部反应均明显低于国产无细胞百白破疫苗。结论进口无细胞百白破疫苗具有接种反应轻微、安全性好的特点。
Objective To compare the vaccine reaction of the local and imported DTaP vaccine. Method 1230 children of 3 months to 2 years old taking the DTaP vaccination in Traditional Chinese Medical Hospital of Tianhe Region in Guangzhou from January to August 2007, were chosen for the study. Their parents have been informed of the safety of the two vaccines and allow them to choose any vaccine for vaccination. The local and wholebody reactions in 24-48 h after vaccination were observed. Result In 725 children vaccinated with the local DTaP vaccine, 84 of them showed local reaction and 108 showed whole-body reaction, with reaction rates of 11.59% and 14.90%, respectively. In 505 children vaccinated with the imported DTaP vaccine, 29 showed local reaction and 41 showed whole-body reaction, with the reaction rates of 5.74% and 8.12%, respectively. There was no significant difference between the two groups in the first, second and third vaccination, but showed significant difference between the two groups in the fourth vaccination. The imported DTaP caused less local and whole-body reactions than domestically produced vaccine in the fourth vaccination. Conclusion The imported DTaP vaccine is proved to be relatively safe and have mild vaccine reactions.
出处
《热带医学杂志》
CAS
2008年第8期830-832,共3页
Journal of Tropical Medicine
