摘要
目的观察联合应用盐酸小檗碱（黄连素，berberin hydrochloride，Ber）对心脏移植受者环孢素A（cyclosporineA，CsA）血浓度的影响。方法观察22例服用CsA心脏移植受者联合服用Ber后CsA全血浓度，肝、肾功能和血脂变化。结果合用Ber后CsA全血稳态C0和C2浓度与合用前比较明显增加（P〈0．01），平均浓度分别增加26％和18％；21例服用CsA剂量减少25～100mg／d，Ber与CsA合用对受者的肝、肾功能及血脂无明显影响（P〉0．05）。结论合用Ber能升高心脏移植受者CsA血浓度，减少CsA服用剂量，节省费用，且无明显不良反应。
Objective To observe the clinic effect of combined use of berberin hydrochloride （Ber） with cyclosporine A （CsA） on the blood concentration of CsA in heart transplanted recipients. Methods The blood con- centration of CsA, liver-renal function and blood lipids in 22 heart transplanted recipients, who received Ber-CsA combined therapy, were measured. Results The whole blood steady state concentration of CsA, Co and C2, in recipients after being treated with Ber-CsA significantly increased than those before applying Ber-CsA （ P 〈 0. 01 ）, with the mean increment of 26% and 18% respectively; the dosage of CsA used decreased in 21 patients by 25-100 mg/d;and the Ber-CsA showed no significant effect on liver-renal function or blood lipids （P 〉 0. 05 ）. Conclusion Combined use of CsA with Ber could markedly increase the blood concentration of CsA in heart transplanted recipients and reduce the dosage of CsA required, save the fee for medical service, and shows no obvious adverse reaction.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2008年第8期702-704,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
盐酸小檗碱(黄连素)
心脏移植
环孢素A
血药浓度
berberin hydrochloride
heart transplantation
cyclosporine A
drug concentration in blood
