摘要
目的观察及评价奥卡西平(OXC)对儿童部分性发作的临床疗效和安全性。方法2006年3月～2007年5月经门诊诊断的PS/CPS或sGTCS儿童患者81例,其中27例采用奥卡西平添加治疗,54例单药治疗,经4～6周加量期和12周稳定期观察后进行评价。结果OXC添加治疗组及单药治疗组总有效率分别为81.5%和83.3%,完全控制率分别为37.0%和40.7%,且不良反应较轻,耐受性良好。结论奥卡西平治疗儿童部分性发作有效且安全,可用于儿童部分性发作的单药治疗和添加治疗。
Objective To evaluate the clinical efficiency and safety of oxcarbazepine for treatment of children with partial seizures. Methods 81 patients suffering from epilepsy were underwent the treatment of oxcarbazepine, of them 27 cases received a oxcarbazepine add-on therapy and 49 cases a monotherapy. The effi- ciency and side effects were evaluated after 6-8 weeks titration period and 12 weeks stabilization period. Results The total effective rate was 81.5% and 83. 3%in add-on group and monotherapy group respectively. The seizure free rate was 37. 0% and 40. 7% in two groups respectively. Side effects were generally mild. ConclusionsOxcarbazepine is a highly effective, safe and widespread first-line antiepileptic drug which can be used as a monotherapy or add-on treatment.
出处
《卒中与神经疾病》
2008年第4期227-229,233,共4页
Stroke and Nervous Diseases
关键词
奥卡西平
癫痫
部分性发作
Oxcarbazepine Epilepsy Partial seizures
