摘要
目的:探讨他汀类药物治疗非缺血性心脏病慢性心衰的疗效。方法:连续入选60例慢性非缺血性心脏病心衰患者,常规标准治疗稳定1月后随机分为阿托伐他汀20mg组(n=28例),安慰剂组(n=32例)。测量基线水平的NYHA分级、血浆脑利钠肽(BNP)、超声心动图的左室射血分数(LVEF)、左室舒张末期内径(LVEDD)以及6分钟步行距离。分别于治疗12周和24周后重复测量上述相关参数。观察其疗效。结果:治疗12周后阿托伐他汀20mg组NYHA分级、BNP以及6min步行距离均显著改善,且优于对照组(P均<0.05);治疗24周后阿托伐他汀20mg组LVEDD、LVEF显著改善,且优于对照组(P均<0.05)。结论:他汀类短期治疗能改善慢性非缺血性心脏病心衰患者的心功能、BNP及6分钟步行距离;中长期治疗有望提高LVEF、缩小LVEDD,所以他汀类有益于慢性心脏病心衰的治疗。
Objective： To investigate the efficacy of statin on non-ischemic heart failure patients. Methods： A total of 60 non ischemic heart failure patients after standard therapy for 1 month were randomly divided into atorvastatin group （n=28） and control group （n= 32）. The changes on the degree of New York heart association （NYHA）, brain natriurenc Peptide （BNP）. left venrricular ejection fraction （LVEF）, left ventricular end-diastolic dimension （LVEDD） and six-minutes walk distance （6MWD） were observed after 12 weeks and 24 weeks. Results： In atorvastatin group, NYHA stage, BNP and 6MWD significantly improved （P〈0.05 all）, and more than those of control group （P〈0.05） after 12 weeks treatments. LVEDD significantly reduced and LVEF significantly increased （P〈 0.05 all） and improved more than those of control group （P〈0.05） after 24 weeks treatments. Conclusion： Statin can improve heart function. BNP and 6MWD in chronic non-ischemic heart failure patients after short-term treatments and may increase LVEF and reduce LVEDD after mid-term or long-term treatments. Statin is helpful for chronic heart failure patients.
出处
《心血管康复医学杂志》
CAS
2008年第4期341-344,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
上海交通大学附属胸科医院科研基金资助项目(YZ06-16)
关键词
心力衰竭
缺血性
阿托伐他汀
利钠肽
脑
心室功能
左
Heart failure, congestive
Atorvastatin
Natriuretic peptide, brain
Ventricular function, left
