摘要
目的：观察短期静脉应用胺碘酮转复老年心房颤动的效果及安全性。方法：42例新发的老年房颤患者，静脉给予负荷量胺碘酮（150～300mg），并以1．0～0．5mg／min静脉维持，观察24h的转复效果及不良反应。结果：33例患者转复窦性心律（82．1％），其中1h内复律3例，1～8h内13例，8～24h内17例，复律后的心率、收缩压和舒张压均显著下降，未复律者的心室率也明显减慢（P〈0．01）。共出现3例窦性心动过缓，1例频发房性早搏，1例一过性低血压，1例静脉炎。结论：静脉应用胺碘酮转复老年新发房颤的短期成功率较高并且相对安全。
Objective： To investigate the efficacy and safety of short-term intravenous amiodarone in the management of atrial fibrillation in the aged. Methods： Forty two patients with recent onset （within 24h） atrial fibrillation were treated with loading dose of amiodarone （150 ～ 300 mg） intravenously, followed by intravenous infusion of amiodarone with the rate at 1.0～0.5 mg/min. The conversion rate and adverse reactions within 24h were observed. Results： At 24h, sinus rhythm was restored in thirty three patients （82.1G）, and at lh, 1-8h, 8-24h, sinus rhythm was restored in three, thirteen and seventeen patients respectively, there were significant decrease in ventricular rate, systolic pressure and diastolic pressure after conversion to sinus rhythm （P〈0.01）; there was also a significant decreased ventricular rate in those who didn＇t restore to sinus rhythm （P〈0.01） . Sinus bradycardia was observed in three patients, one patient had frequent atrial premature beats, one patient had transient hypotension and one patient had phlebitis. Conclusion： Short-term intravenous amiodarone has a high conversion rate and relative safety in the treatment of recent onset atrial fibrillation in the aged.
出处
《心血管康复医学杂志》
CAS
2008年第4期388-391,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心房颤动
胺碘酮
老年人
Atrial fibrillation
Amiodarone
The aged
