摘要
氧是生命体维持能量代谢和各种生命活动的必需元素,在干细胞功能调控中发挥重要的作用。缺氧是实体瘤组织的重要特征,最近的一系列研究表明缺氧是肿瘤干细胞发生和转移的重要环节,这一思路丰富了人们对肿瘤干细胞局部微环境调控机制的认识,也为肿瘤的靶向治疗提供了新的线索。
The oxygen is the essential element for energy metabolism and all kinds of activity in a body;it plays the vital role in the stems cell function regulation. Hypoxia is a key feature in solid tumor. Recently, a series of research indicated the hypoxia is very important on tumor stem cell occurs and metastases, this find has enriched the understanding about tumor stem cell micro - environment regulation mechanism. Hypoxia research maybe a new clue for the tumor target therapy.
出处
《现代肿瘤医学》
CAS
2008年第9期1645-1648,共4页
Journal of Modern Oncology
基金
陕西省科技计划项目(编号:2005K09-G6)
关键词
肿瘤干细胞
缺氧
tumor stem cell
hypoxia
