摘要
目的:改进硼酸滴耳液制备方法。方法:利用超声波代替水浴加热促进硼酸溶解以制备滴耳液,并对上述2种制备方法进行比较。结果:所制制剂为无色澄清液体,质量检查等均符合《浙江省医院制剂规范》;与水浴加热法相比,超声波法可显著缩短制备所消耗的时间,分别为(29±4.2)、(18±1.4)min。结论:该制剂改进的制备工艺简便可行,质量稳定可控。
OBJECTIVE： To improve the preparative method of boric acid ear drops. METHODS： Boric acid ear drops were prepared using ultrasonic wave rather than waterbath heating to accelerate the solution of boric acid, and a comparison was conducted between the ultrasonic method and the waterbath heating method. RESULTS： The prepared boric acid ear drops were colorless supernatant liquid, which met the standard stated by the ＂Stipulations of clinical preparations in Zhejiang Province＂ in tests, identification and content. By ultrasonic method, the time spent for preparing boric acid ear drops was shorter （29 ± 4.2） min than by waterbath heating method （18 ± 1.4） min. CONCLUSION： The improved preparative method for boric acid ear drops is simple and feasible and the quality of the preparation is stable and controllable.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第25期1967-1968,共2页
China Pharmacy
关键词
硼酸滴耳液
超声波
方法改进
质量控制
Boric acid ear drops
Ultrasonic wave
Improvement
Quality control
