摘要
目的探讨丹红注射液对急性脑梗死患者血浆内皮素(ET)、血清丙二醛(MDA)、超氧化物歧化酶(SOD)的影响。方法将96例急性脑梗死患者随机分为A、B两组,各48例。常规治疗基础上,A组给予丹红注射液治疗,B组给予复方丹参治疗,均治疗14d。观察治疗前后患者血浆ET、MDA、SOD水平变化,对两组患者治疗前后神经功能缺损评分进行比较,并与46例健康者(C组)进行比较。结果急性脑梗死患者(A、B组)ET、MDA、SOD水平与C组比较,差别有统计学意义(P<0.01);A组患者治疗后ET、MDA、SOD水平及神经功能缺损程度评分较B组差别有统计学意义(P<0.05)。结论丹红注射液能降低急性脑梗死患者血浆ET水平及增强的脂质过氧化反应,纠正抗氧化酶的失衡,改善神经功能缺损,临床疗效肯定。
Objective To investigate the effection of Danhong injection on determination of plasma endothelin （ET）, serum malondialdehyde （MDA）, superoxide dismutase （SOD）, and the clinical therapeutic efficacy in acute cerebral infarction. Methods Ninety - six patients with acute brain infarction were randomly allocated to two groups, forty - eight cases in each group. Besides the routine treatment, the patients of treatment group were treated with Danhong injection and patients of control group were treated with Dansen injection respectively for 14 days. Plasma ET, serum MDA, SOD and the neurological functional scores were measured before and after the treatment. Data were compared between the two groups and also compared with those measured in 46 healthy subjects for control. Results The levels of ET and MDA were higher significantly in acute cer- ebral infarction patients than those in healthy subjects （ P 〈 0. 01 ）, and the level of SOD was lower （ P 〈 0. 01 ）. After the treatment, the hvels of ET and MDA decreased and the activity of SOD rose in the treatment group （ P 〈 0. 05）, which had a significant difference from the control group （ P 〈 0.05）. Improvement of neural function injure in the treatment group were superior to that in the control group （ P 〈 0.05）. Conclusion Danhong injection can significantly reduce the level of ET and attenuate markedly lipid peroxide reaction, correct the imbalance of the antioxidant enzymes, improve the nerve function.
出处
《实用心脑肺血管病杂志》
2008年第7期6-7,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
脑梗死
丹红注射液
内皮素
超氧化物歧化酶
丙二醛
Brain infarction
Danhong injection
Endothelin
Superoxide dismutase
Malondialdehyde
