摘要
目的观察博莱霉素(BLM)胸腔内灌注治疗恶性胸腔积液的疗效及毒副作用。方法恶性胸腔积液32例均采用中心静脉导管闭式引流,排尽胸水后胸腔内灌注博莱霉素(BLM)局部治疗,在胸水再生的情况下1周后重复引尽胸水及腔内给药。结果完全缓解(CR)10例,部分缓解(PR)14例,无效(NC)8例,有效率(RR)75%。结论胸腔内灌注BLM治疗癌性胸水效果好,毒副反应少,耐受性好,值得临床推广。
Objective To investigate the toxicity and therapeutic effect of chemical pleurodesis with Bleomycin （BLM）. Methotis 32 consecutive, unselected patients of malignant pleural effusions were enrolled on the study. Using image guidance, a 14F self-retaining catheter was inserted into the pleural space and connected to continuous wall suction. After drainage, pleurodesis was performed with 45 - 50 mg of bleomyein. One week later using image reevaluation, the patients who still had pleual effusions received the second pleurodesis. Results Ten patients had a complete response （ CR）, and 14 patients had a partial response （ PR）, 8 patients had a noncure （NC）. The total response rate （RR） reached 75 %. Conclusion Chemical pleurodesis may be effective with low toxicity and strong tolerance in the treatment of patients with malignant pleural effusions. It deserves further clinical applications.
出处
《临床肺科杂志》
2008年第10期1271-1272,共2页
Journal of Clinical Pulmonary Medicine
关键词
恶性胸腔积液
博莱霉素
胸腔内灌注
malignant pleural effusions
bleomycin
chemical pleuredesis
