摘要
目的测定对乙酰氨基酚原料和片剂中的有关物质对氨基酚。方法离子交换色谱法,采用DionexIonpacCG12分离柱,淋洗液为80 mmol/L H2SO4溶液(内含3%CH3CN,作为有机改性剂),紫外检测波长265nm。结果对氨基酚质量浓度在0.2～50.0mg/L范围内与峰面积线性关系良好(r=0.9997),最低检测限为0.2961μg/L(S/N=3)。结论所用方法准确、灵敏、简便,可用于对乙酰氨基酚原料和片剂中有关物质对氨基酚的测定。
Objective To establish a method for the determination of 4- aminophenol in the raw materials and tablets of paraeetamol by IEC with UV detection. Methods The chromatographic separation was achieved on a Dionex Ionpae CG12 column. The eluent was the mixed solution containing 80 mmol/L H2SO4 and 3% CH3CN. The ultraviolet detection wavelength was 265 nm. Results The correlation coefficient of calibration curves in the range 0.2-50.0 mg/L for 4-aminopehenol was 0. 999 7. The lowest detectable limits for 4- aminophenol was 0. 296 1 ug/L（ S/N = 3）. Conclusion The proposed method enables accurate, sensitive, rapid analysis for 4- aminophenol in the raw materials and tablets of paracetamol.
出处
《中国药业》
CAS
2008年第17期15-16,共2页
China Pharmaceuticals
