摘要
目的探讨重型病毒性肝炎(重肝)患者甲胎蛋白的变化及其临床意义。方法选取重肝患者77例分为两组,分别对患者在疾病早期、缓解期和恶化期甲胎蛋白(AFP)水平进行检测,同时检测患者凝血酶原活动度(PTA)、总胆红素(TBIL)和丙氨酸氨基转移酶(ALT)水平。结果早期好转组(45例)与恶化组(32例)间:AFP变化差异无统计学意义,AFP与PTA、TBIL、ALT相关性均不明确。整个病程中AFP变化与病情缓解程度一致,病情越轻,AFP越高,与文献中的PTA、TBIL、ALT变化趋势相同,AFP与PTA、TBIL具有很好的相关性。结论重肝甲胎蛋白变化对早期诊断可能无帮助,但可用于重肝评估病情严重程度及判断患者预后。
Objective To explore the changes and clinical analysis of alpha fetoprotein （AFP） in patients with Severe Hepatitis. Methods 77 patients were involved in the present study. The changes of AFP were tested in the early, the recovery and the worsen stage. Meanwhile, the plasma levels of PTA TBIL and ALT were tested. Results In the recover and the worsen patients, there were no significant difference with AFP （P〉0. 05）. The changes of AFP were no related to the changes of PTA TBIL and ALT. The changes of AFP were consistent with the state of illness. The changes of AFP were related to the changes of PTA and TBIL. Conclusion The changes of AFP can not be used to diagnosis the severity of hepatitis, but it can be used to assess the condition and judging the prognosis of hepatitis patient.
出处
《西部医学》
2008年第5期1060-1062,共3页
Medical Journal of West China
关键词
重型肝炎
甲胎蛋白
肝炎
Severe Hepatitis
Alpha fetoprotein
Hepatitis
