期刊文献+

叶酸、B族维生素对高同型半胱氨酸血症脑梗死患者血管内皮细胞功能的影响 被引量:11

下载PDF
导出
摘要 将120例高同型半胱氨酸(Hcy)血症的脑梗死患者随机分为治疗组和对照组,治疗组口服叶酸、维生素B6、维生素B12,对照组不服用上述药物。治疗前和治疗4周后分别测定血浆Hcy水平及内皮素(ET)、一氧化氮(NO)水平。发现治疗组治疗4周后,血浆Hcy、ET水平明显降低,NO水平明显升高。提示叶酸、B族维生素干预治疗能降低血浆Hcy水平,对高Hcy血症脑梗死患者血管内皮细胞功能损害有一定的改善作用。
出处 《山东医药》 CAS 北大核心 2008年第27期76-77,共2页 Shandong Medical Journal
  • 相关文献

参考文献4

二级参考文献32

  • 1张颖冬.阿司匹林防治缺血性脑血管病中的阿司匹林抵抗[J].临床神经病学杂志,2005,18(3):161-163. 被引量:31
  • 2Blundell G,Jones BG,Ross FA,et al.Homocysteine mediated endothelial cell toxicity and its amelioration[J].Atherosclerosis,1996,122(2):163-172.
  • 3Hofmann MA,Kohl B,Zumbach MS,et al.Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM[J].Diabetes Care,1997,20(12):1880-1886.
  • 4Gibson JB,Carson NA,Neill DW.Pathological findings in homocystinuria[J].J Clin Pathol,1964,17(4):427-437.
  • 5McCully KS.Vascular pathology of homocysteinemia:implications for the pathogenesis of arteriosclerosis[J].Am J Pathol,1969,56(1):111-128.
  • 6Furchgott RF,Zawadzki JV.The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine[J].Nature,1980,288(5789):373-376.
  • 7Suwaidi JA,Hamasaki S,Higano ST,et al.Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction[J].Circulation,2000,101(9):948-954.
  • 8Schachinger V,Britten MB,Zeiher AM.Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease[J].Circulation,2000,101(16):1899-1906.
  • 9Stampfer MJ,Malinow MR,Willett WC,et al.A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians[J].JAMA,1992,268(7):877-881.
  • 10Soriente L,Coppola A,Madonna P,et al.Homozygous C677T mutation of the 5,10 methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in Italian patients with a history of early-onset ischemic stroke[J].Stroke,1998,29:869-870.

共引文献31

同被引文献92

引证文献11

二级引证文献181

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部