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英夫利昔单抗在炎症性肠病治疗中的应用 被引量：21

Infliximab in inflammatory bowel disease
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摘要 克罗恩病(CD)和溃疡性结肠炎(UC)是两种特发性肠道炎性疾病。此文对新出现的生物制剂之一,英夫利昔单抗(infliximab)在这类疾病中实际应用方面的依据进行评论和回顾,包括剂量、疗效、注意事项和不良反应,并作一总结。 Crohn＇s disease and ulcerative colitis are two idiopathic intestinal inflammatory diseases, This article comments and reviews on the infliximab which is one of the new biologic agents, includes dosage,curative effect,caution and toxicity.
作者 冯楠 戈之铮
机构地区 上海交通大学医学院附属仁济医院消化科
出处 《国际消化病杂志》 CAS 2008年第4期273-276,共4页 International Journal of Digestive Diseases
关键词 炎症性肠病 英夫利昔单抗 抗TNF—α抗体 Inflammatory bowel disease Infliximab Anti-TNF-α
分类号 R574 [医药卫生—消化系统] R392.11 [医药卫生—免疫学]
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参考文献28

  • 1Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn' s disease. N Engl J Med, 1997, 337: 1029-1035.
  • 2D'Haens G, Van Deventer S, Van Hogezand R, et al. Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial. Gastroenterology, 1999,116 : 1029-1034.
  • 3Sands BE, Tremaine WJ, Sandborn WJ, et al. Infliximab in the treatment of severe, steroidrefractory ulcerative colitis: a pilot study. Inflamm Bowel Dis,2001,7:83-88.
  • 4Jarnerot G, Hertervig E, Friis-Liby I, et al. Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study. Gastroenterology,2005, 128:1805-1811.
  • 5Comerford LW, Bickston SJ. Treatment of luminal and fistulizing Crohn's disease with Infliximab. Gastroenterol Clin North Am, 2004,33 : 387-406.
  • 6Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med,1999,340:1398-1405.
  • 7Sandborn WJ, Hanauer SB. Infliximab in the treatment of Crohn's disease:a user's guide for clinicians. Am J Gastroenterol, 2002,97 : 2962-2972.
  • 8Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT Ⅰ randomised trial. Lancet,2002, 359:1541-1549.
  • 9Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med, 2005,353 : 2462-2476.
  • 10Rutgeerts P, Feagan BG, Olson A, et al. A randomized placebo controlled trial of infliximab therapy for active ulcerative colitis: Act 1 Trial, 2005,127 : A105.

同被引文献157

引证文献21

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国际消化病杂志
2008年 第4期

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