摘要
目的观察前列地尔注射液联合甲钴胺治疗糖尿病勃起功能障碍(ED)的近期疗效。方法112例2型糖尿病合并ED病人在饮食控制和胰岛素治疗的基础上,给予前列地尔注射液10μg,甲钴胺500μg静脉滴注,每日1次,连用3 wk。治疗前后根据国际勃起功能指数表(IIEF-5)病人进行自我评分,并观察治疗前后尿微量清(白)蛋白排泄率(UAER)、肝功能、肾功能、血脂等指标的变化。结果治疗后IIEF-5总评分和各问题的评分均显著高于治疗前(P<0.05,0.01),UAER下降显著(P<0.01)。结论前列地尔注射液联合甲钴铵治疗糖尿病ED具有良好效果。
AIM To observe the short term effect of combined alprostadil injection and mecobalamin on type 2 diabetic patients with erectile dysfunction （ED）. METHODS One hundred and twelve diabetic patients with ED under diet and insulin control were given alprostadil injection 10μg·d^-1 and mecobalamin 500μg·d^-1 for 3 wk. The international index of erectile function 5 （IIEF-5） was used for self evaluation and the urine albumin eliminate rate （UAER）, hepatic function, renal function, low density cholesterol, total cholesterol and triglyceride were determined before and after the treatment, respectively. RESULTS Improvements in mean scores of IIEF-5 and each item of IIEF-5 were significantly better in patients received alprostadil and mecobalamin comparing with those of pretreatment. The UAER decreased significantly, while the hepatic function, renal function, low density cholesterol, total cholesterol and triglyceride showed no significant change and no adverse reaction were found during the study. CONCLUSION Combined therapy of alprostadil and mecobalamin is rather effective for diabetic patients with ED.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2008年第8期589-591,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
阳萎
糖尿病
2型
前列地尔
甲钴铵
impotence
diabetes mellitus, type 2
alprostadil
mecobalamin
