支气管哮喘患儿急性发作期血清白细胞介素-25、12的变化及其意义被引量：15

Changes of Serum Interleukin-25,12 in Children with Asthma and Their Clinical Significance

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摘要目的探讨哮喘患儿急性发作期血清IL-25、12水平变化及其在哮喘发病中的作用。方法随机选取于本院就诊的哮喘急性发作期患儿30例作为观察组。男20例,女10例;年龄4～13岁;发作程度:轻度8例,中度17例,重度5例。随机选取同期同年龄组健康体检儿童27例作为健康对照组。男18例,女9例;年龄4～14岁。二组年龄及性别均无统计学差异(Pa>0.05)。分别抽取各组儿童静脉血4mL,离心后留取血清标本置-70℃冰箱保存,采用ELISA法测定二组儿童血清IL-25、12水平。结果哮喘急性发作期患儿血清IL-25水平[(56.75±11.68)ng/L]显著高于健康对照组[(45.77±10.43)ng/L],差异有统计学意义(t=3.726P<0.05);哮喘急性发作期患儿血清IL-12水平[(42.12±12.96)ng/L]显著低于健康对照组[(57.12±14.42)ng/L],差异有统计学意义(t=-4.136P<0.05);血清IL-25水平与IL-12水平呈显著负相关(r=-0.420P<0.01)。结论哮喘患儿急性发作期血清IL-25水平升高和IL-12水平降低与哮喘的发作关系密切。增强IL-2的活性,可为哮喘的治疗提供新的靶点与理论依据。

作者张永梅徐青安肃英李芳段国威孙艳霞

机构地区河北医科大学第二医院儿科

出处《实用儿科临床杂志》 CAS CSCD 北大核心 2008年第16期1262-1263,共2页 Journal of Applied Clinical Pediatrics

基金河北省科学技术研究计划项目资助(052761226) 河北省2007年医学科学研究重点课题计划项目资助(07227)

关键词哮喘白细胞介素-25 白细胞介素-12 儿童

分类号 R725.6 [医药卫生—儿科]

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参考文献10

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