摘要
目的检测皮肤鳞状细胞癌中eIF-4E、p53的表达,以探讨它们的临床意义。方法用免疫组化SABC法分别检测7例正常成人皮肤以及32例皮肤鳞状细胞癌中eIF-4E、p53的表达水平。结果在正常表皮中eIF-4E、p53表达均为阴性。在皮肤鳞状细胞癌中的表达率分别为93.8%和56.3%,明显高于正常成人皮肤(P<0.05)。结论在皮肤鳞状细胞癌中,eIF-4E、p53均可作为肿瘤标志物,且eIF-4E蛋白表达率高、特异性强,是一种更具潜质的肿瘤标志物。
Objective To study the expression of eIF-4E and p53 in squamous cell carcinomas （SCC） and to explore their relationship and clinical significance. Methods The expression of eIF-4E and p53 in 32 cases of SCC was detected by immunohistochemical SABC method. Results The positive rate of eIF-4E and p53 expression was 93.8% and 56.3% in SCC, and the levels of eIF-4E and p53 were significantly higher in SCC than those in the normal skin tissue （P〈0.05）. Conclusion Both eIF-4E and p53 were useful markers in SCC, but the specialty and sensitivity of the eIF-4E protein was high in SCC.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2008年第4期512-513,516,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
