摘要
目的探讨乳腺Paget病中细胞角蛋白-8(CK-8)、c-erbB-2、雌激素受体(ER)和孕激素受体(PR)的表达及意义。方法对12例乳腺paget病组织进行免疫组织化学染色,检测CK-8、c-erbB-2、ER、PR在Paget细胞与同一例深部癌组织中表达的异同。结果Paget细胞CK-8表达阳性率为100%、c-erbB-2表达阳性率为91.67%,而ER、PR表达阳性率为16.67%。CK-8、c-erbB-2、ER及PR中每一标记物在Paget细胞和同一病例深部癌组织中阳性表达一致。结论乳腺Paget病内Paget细胞来源于乳腺深部存在的导管内癌或浸润性导管癌,是深部癌细胞在表皮内的扩散。
Objective To investigate the expression and significance of cytokeratin-8 （CK-8）, c-erbB-2, estrogen receptor（ER） and progesterone receptor （PR） in mammary Paget disease. Methods Paget＇s disease of the breast was analyzed for these molecular markers by immunohistochemical staining. Both of the intraepidermal Paget cells and the underlying carcinoma cells were assessed for CK-8, c-erbB-2, ER and PR. Results In paget cells, the positive sate of CK-8 was 100%, thatof c-erbB-2 was 91.67%, that of ER and PR were 16.67%. The positive rate of these molecular markers was similar in both Paget cells and the underlying intraductal and/or ductal carcinoma cells. Conclusion The results of the preseut study illuminate the intraepidermal Paget cells root in the underlying carcinoma.
出处
《解剖学研究》
CAS
2008年第4期258-260,共3页
Anatomy Research
