摘要
目的通过检测进一步了解TGF-β1、NOS2在骨关节炎(OA)滑膜组织中的表达及相关性。方法应用免疫组化方法检测TGF-β1和NOS2在滑膜组织中的表达情况,结果用Spearman等级相关检验方法进行统计学分析。结果TGF-β1和NOS2的阳性表达率分别为60%和13.3%。TGF-β1和NOS2表达间的相关性无统计学意义(rs=0.306,P>0.05)。结论TGF-β1与NOS2在骨关节滑膜组织中的表达没有相关性,TGF-β1的表达率较正常组织为低,NOS2的表达率较正常组织高,TGF-β1和NOS2的改变是OA发生、发展的重要介导因素。
Objective To investigate the expression rate of TGF-β1 and NOS2 in the synovial membrane of osteoarthritis（OA） ,and to study the relationship between the two factors. Methods The synovial membrane of osteoarthritis were immunohistochemically detected with TGF-β1 and NOS2 , respectively. The results were analyzed with spearman＇s rank correlation. Results The expression rates of TGF-β1 and NOS2 were 60% ,13. 3% ,respectively. The correlation coefficient between TGF-β1 and NOSz was not statistically significant（ G = 0. 306, P 〉 0.05）. Conclusions The expression of TGF-β1 and NOS2 on the synovial membrane of osteoorthritis is irrelevant. The expression rate of TGF-β1 in osteoarthritis is relatively lower than in normal tissues ,though NOS2 is relatively higher. The two factors are associated with destructive process in OA.
出处
《临床骨科杂志》
2008年第4期363-366,共4页
Journal of Clinical Orthopaedics
基金
淄博市科委课题基金项目(编号:2003-0051)
关键词
骨关节炎
滑膜
转化生长因子Β1
一氧化氮合酶
osteoanhritis
synovial membrane
transforming growth factors β1
nitric-oxide synthase
