摘要
随着各种新药的广泛应用以及联合用药的增多,药源性肝损伤的发生率明显增高,按其发病机制可分为药物及其活性代谢物直接造成的可预测的肝损伤及药物特异质反应所致的不可预测的肝损伤两大类。综述近年来对药源性肝损伤的发病机制的研究进展,为预防药源性肝损伤提供思路。
Along with the application of new drugs and drug combination, the incidence of druginduced liver injury （DILI） has increased in recent years. According to pathogenesy, it can be divided into two kinds of DILI： injury caused directly by predictable drugs as well as their reactive metabolites and that caused by unpredictable drug idiosyncratic reactions. This paper provides the overview of research progresses on the pathogenesy of DILI, and thus gives thoughts on the prediction and prevention of DILI.
出处
《药学进展》
CAS
2008年第8期357-362,共6页
Progress in Pharmaceutical Sciences
基金
中医药行业科研专项(No.200707008)
关键词
药源性肝损伤
肝毒性
线粒体
天然性免疫
适应性免疫
Drug-induced liver injury
Hepatotoxicity
Mitochondrion
Innate immunity
Adaptive immunity
